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The confrontation turned violent; the BBC, citing correspondents, reported that each side blamed the other. The protesters fought with crude weapons such as large rocks and bats , firearms, and improvised explosives Molotov cocktails ,  and broke into the headquarters of the Party of Regions.
Police officers stormed the main protest camp on Maidan Nezalezhnosti and overran parts of the square. Political commentators suggested that Ukraine was on the brink of a civil war.
On 19 February, the authorities instituted police checkpoints, restrictions on public transportation, and school closures in Kiev, which the media referred to as a de facto state of emergency.
On 20 February, Internal Affairs Minister Vitaliy Zakharchenko announced that he had signed a decree authorising the use of live ammunition against protesters.
On 21 February, President Yanukovych signed a compromise deal with opposition leaders. It promised constitutional changes to restore certain powers to Parliament and called for early elections to be held by December.
On 22 February, the protesters were reported to be in control of Kiev, and Yanukovych was said to have fled the capital for eastern Ukraine.
Parliament named its speaker, Oleksandr Turchynov , as interim president on 23 February. On 28 February, Yanukovych attended a press conference in southern Russia and answered questions from mostly Russian reporters.
He said that the early presidential elections scheduled for late May were illegal and that he "would not be participating in them".
He also said that while the 21 February agreement could have calmed the situation, the opposition had not agreed to it. Protests originally erupted in November after Yanukovych refused to sign a political association and free trade agreement with the European Union at a meeting of the Eastern Partnership in Vilnius, Lithuania , choosing closer ties with Russia instead.
The European Union and the United States urged Yanukovych to negotiate a peaceful end to the conflict and said they would impose sanctions on government officials if they were found responsible for violence.
On 14 February, Yanukovych had said: The perception that Yanukovych was trying to establish closer ties with Russia played a major role in the protests.
In an interview on 20 February, a retired  colonel of the Main Intelligence Directorate of Russia GRU , Aleksandr Musienko, said that the conflict could only be solved by force, and that Ukraine had proven it could not exist as an independent, sovereign state.
Before some police officers defected, the plans included the deployment of 22, combined security troops in Kiev.
On 21 February, after a failed crackdown that killed as many as people, Yanukovych made some concessions. In response, Prime Minister Dmitry Medvedev of Russia said that Yanukovych needed to stop behaving like a "doormat", and that further loan installments would be withheld.
A Russian political adviser, Sergey Markov , said, "Russia will do everything allowable by law to stop [the opposition] from coming to power.
The FSB rejected these claims as "groundless accusations" and otherwise refused to comment. Ukraine will make Europe better and Europe will make Ukraine better, we are here to support your just cause, the sovereign right of Ukraine to determine its own destiny freely and independently.
Specifically, which roles the prominent opposition leaders should pursue:. We want to try to get somebody with an international personality to come out here and help to midwife this thing.
Nuland was also recorded in the same conversation saying, "F Dismissively referring to slow-moving European efforts to address political paralysis and a looming fiscal crisis in Ukraine.
The night before the clashes, Right Sector called on all of its members to ready themselves for a "peace offensive" on 18 February.
The Maidan Union reported on the morning of 18 February that columns of protesters would begin a march on Parliament at That morning, around 20, demonstrators marched on the Verkhovna Rada  as Parliament was set to consider opposition demands for a new constitution and government.
As the column neared the Verkhovna Rada building at The protesters forced their way to the roof, forcing the police to retreat.
Berkut and Internal Troops servicemen opened a full-scale assault, firing directly into the crowd. By mid-afternoon, police officers using tear gas drove as many as 10, protesters from Mariinsky Park, where barricades had been built earlier in the day.
Demonstrators threw stun grenades, filling the park with smoke. Other anti-government activists tried to keep the pro-government and anti-government forces apart.
Multiple news outlets published photographs showing the police armed with AK assault rifles. Protesters re-occupied City Hall. Following the warning, the police advanced on thousands of protesters on Maidan Nezalezhnosti Independence Square with guns, a water cannon, and an armored personnel carrier.
Tents housing protesters were burning on the main square. Presidential adviser Hanna Herman said that negotiations between the government and the opposition would only happen once peace was restored and the crowds retreated, and that "calling further for armed conflict is a great crime against the Ukrainian people and the Ukrainian state.
The activists believed that this heralded the beginning of a decisive assault. Emerging from a meeting with President Yanukovych, opposition leader Vitali Klitschko told Hromadske TV that the talks had not been successful.
The president also demanded that the opposition force the protesters to leave Maidan Nezalezhnosti. In a message on Ukrainian television , Yanukovych told the opposition leaders, "Separate yourself from the radical elements that seek bloodshed and conflict with law enforcement agencies," and said that if they did not, he would "talk differently" with them.
The line had been crossed when they called people to arms. This is our principled position. The death of each person is a personal tragedy for each of us.
People will decide themselves what to do depending on when and how their demands are satisfied. The Kiev Metro was closed and main roads blocked by police.
In the early morning, titushky shot two protesters, killing one. The Security Service of Ukraine SBU launched an "anti-terrorist" operation, while the intelligence services began investigating unnamed politicians over what was described as an illegal attempt to seize power.
In the early morning, Olena Lukash announced that the opposition had refused to sign a declaration disapproving of radical measures. President Yanukovych demanded that the opposition stop occupying buildings and seizing arms; the opposition, however, would not concede.
Also on 19 February, a military An made a secret flight from Kiev to Russia to pick up a large batch of anti-riot weapons and ammunition; this only became known in A Euronews correspondent on Independence Square reported that protesters were arriving "from all parts of Ukraine".
President Yanukovych fired the chief of the general staff of the Ukrainian Armed Forces, Volodymyr Zamana, and replaced him with Ilyin, who was previously the commander of the Ukrainian Navy.
The European Investment Bank froze activities in Ukraine,  saying, "For the time being, the situation is so cruel that it would be politically the wrong signal, but also irresponsible vis-a-vis the people we asked to do the job, to be active on business in Ukraine.
Following a meeting between government and opposition leaders late at night, both sides declared a truce and agreed to start negotiations.
Each side blamed the other for igniting the deadly conflict. They are using firearms, including sniper rifles.
They are shooting to kill," it said. Those with minor injuries were treated by medics. The head of the Kiev City State Administration , Volodymyr Makeyenko , resigned from the Party of Regions but said he would continue to perform his duties to ensure that the city functioned properly.
The Embassy of the United Kingdom in Kiev was temporarily closed. Radio Liberty published video footage of police special forces shooting protesters with Kalashnikov and sniper rifles.
Interfax-Ukraine reported that at There is no solution other than elections. Further talks were scheduled to negotiate the signing of the relevant document.
The United States imposed visa bans on 20 Ukrainian officials it considered "responsible for ordering human rights abuses related to political oppression".
Party of Regions MP Sergiy Tigipko called for the resignation of Parliament Speaker Volodymyr Rybak , his replacement with an opposition parliamentarian, and the urgent election of a prime minister supported by all factions.
Ten Party of Regions and two independent MPs [nb 2] called for a return to the parliamentary-presidential form of government. Late in the evening, it was announced that five more MPs had left the parliamentary faction of the Party of Regions.
The Parliament of Crimea called for an extraordinary session on 21 February. The leader of the Mejlis of the Crimean Tatar People said he suspected that lawmakers would ask for Russian military intervention, stating, "Tomorrow may be a decision that will bring chaos and disaster to Crimea.
Later, Maidan activists released the Interior Troops servicemen whom they had captured the previous day.
The Security Service of Ukraine officially ended its "preparations for antiterrorist operation" introduced on 19 February. Parliament voted unanimously, —0, to return to the constitution, and then —0 to suspend acting Interior Minister Zakharchenko.
Right Sector leader Dmytro Yarosh rejected the agreement, saying, "We have to state the obvious fact that the criminal regime had not yet realised either the gravity of its evil doing.
Vitali Klitschko apologised to the crowd on Independence Square after shaking hands with Yanukovych. Activist Volodymyr Parasiuk warned from the stage that if Yanukovych did not resign by By late afternoon, hundreds of riot police officers guarding the presidential compound and nearby government buildings had vanished.
Deputy Interior Minister Viktor Dubovik ordered the riot police to leave the city, but it is unclear where this order originated.
After the first day of clashes, 26 people were reported dead: Those hospitalised included three minors, five journalists, and 79 police officers.
From 18—19 February, the official death toll according to the Ministry of Healthcare was 28, of whom 10 were police and Berkut troops. Paet; that she had not implied that the opposition was involved in the killings; and that the government had informed her that an investigation was underway.
This was all done in order to escalate the conflict, in order to justify the police operation to clear Maidan. He further suggested that the current minister of internal affairs, Avakov, and the chairman of the SBU, Nalivaichenko, were protecting the personnel who actually planned and carried out the killings, in order to prevent backlash against the ministry and to avoid a loss of prestige.
The media suggested that it was not the Ukrainian riot police who fired on the protesters, as previously believed, although the members of the Alpha team are Ukrainian citizens.
On 21 February, President Yanukovych and Parliament declared 22 and 23 February to be days of mourning "due to the loss of human life as a result of mass disturbances".
Speaker Rybak submitted his resignation in parliament on February 22, citing illness. Oleksandr Turchynov said that most of the ministers had disappeared, including Interior Minister Zakharchenko, who was reported to have fled to Belarus.
Instead, Parliament declared that Yanukovych "withdrew from his duties in an unconstitutional manner" and cited "circumstances of extreme urgency" as the reason for early elections.
Turchynov claimed that Yanukovych had agreed to resign as president, but after consulting with advisers, he disavowed that and even pre-recorded a resignation statement.
Following the parliamentary procedures to transfer power to the new provisional government, General Prosecutor Pshonka and Minister of Revenues and Duties Oleksandr Klymenko were stopped at the Russian border while trying to flee the country.
According to the State Border Service, Yanukovych also tried to flee via a charter flight from Donetsk, but was stopped by border guards.
The guards were "met by a group of armed men who offered money for flying without the proper clearance". Yanukovych then left by armored car, and his subsequent whereabouts were unknown.
On 23 February, Parliament deputy Oleh Lyashko claimed that Yanukovych had been seen at the Russian naval base in Sevastopol, preparing to flee the country on board a Russian military vessel.
On 25 February, Parliament asked the International Criminal Court to "establish and bring to justice" senior Ukrainian officials, including Yanukovych, for crimes against humanity committed during "peaceful protests of citizens" from 21 November to 22 February Yanukovych; the former head of the presidential administration, Andriy Kliuyev; former Prosecutor General Pshonka; former Interior Minister Zakharchenko; former SBU head Yakymenko; the commander of the Interior Troops, Stanislav Shuliak; and a number of others were declared suspects in the case.
On 22 February, Yulia Tymoshenko was released from prison and addressed more than , people on Independence Square. On 23 February, the second day of national mourning, Parliament voted to abolish the law on language policies that had given the Russian, Romanian, and Hungarian languages the official status of regional languages in some areas.
On Tuesday, 25 February, acting President Turchynov called for the formation of a national unity government by Thursday. On 26 February, Turchynov assumed the duties of the supreme commander-in-chief of the Ukrainian Armed Forces.
On 27 February, judges of the Constitutional Court sent a letter to European organizations, international organizations, and human rights institutions questioning the constitutionality of the parliamentary resolution.
The law on lustration, which excluded from government most officials who had worked in the Yanukovych administration, affected up to a million people.
The Security Service of Ukraine arrested the former chief of its counterintelligence service, Volodymyr Byk. On 18 February at The metro became fully operational again, including the reopening of the Maidan Nezalezhnosti station , on 24 February.
According to Cathy Young , in the Antimaidan protests against the revolution, street posters, Internet posts, and even speeches at rallies attacked the new government as a "Jewish clique" seeking to use Ukrainians to defend the interests of wealthy Jews, and depicted the revolution as a "Zionist coup.
The pro-Russian Ukrainian Front organisation held a meeting on 22 February with representatives from southern and eastern Ukraine. At the Congress of the Southern and Eastern regions in Kharkiv on 22 February, the deputies passed a resolution declaring that they were ready to take responsibility for protecting constitutional order in their territory.
They stated that the recent events in Kiev had paralyzed the central government and destabilised the country.
If signed by the president, the bill would have established Ukrainian as the sole official state language of Ukraine, including Crimea, which is populated by a Russian-speaking majority.
Also on 23 February, clashes erupted in Kharkiv between thousands of equally sized pro- and anti-government rallies, and Mayor Kernes was blocked from entering the City Council building.
On 24 February, acting Interior Minister Avakov announced that a criminal case had been launched against Yevhen Zhylin, leader of the Kharkiv-based anti-Euromaidan organisation Oplot.
Half of respondents believed that President Turchynov was "illegally occupying his post". Roughly half held the same opinion about the central government led by Prime Minister Yatsenyuk.
Following the Ukrainian revolution, a secession crisis began in the Russian-leaning Crimean Peninsula. On 1 March , Yanukovych put into writing his request that President Putin of Russia send military forces "to establish legitimacy, peace, law and order, stability and defending the people of Ukraine".
By 2 March, Russian troops had complete control over Crimea. The monument to the Russian field marshal Mikhail Kutuzov was demolished in the city of Brody in western Ukraine.
Starting on 18 February, Euromaidan activists occupied regional state administration RSA buildings in several oblasts regions.
Dynamo Kyiv and the other clubs competing in the Round of 32 held a minute of silence for the victims in Kiev before the match, and the athletes played wearing mourning armbands.
On 3 March, a scheduled friendly match between the United States and Ukraine in Kharkiv was moved to Nicosia because of safety concerns regarding potential instability in Kharkiv Oblast.
On 20 February, Parliament resumed its work around Members adopted a draft law that expressed "condemnation of the violence that led to the deaths of peaceful citizens of Ukraine".
On the morning of 21 February, Parliament announced that Speaker Rybak had signed a resolution titled "About condemning violence in Ukraine, which led to loss of life".
The resolution ordered the Cabinet of Ukraine and all siloviks to stop the use of force and prohibited the use of any weapons and special measures against citizens of Ukraine.
From Wikipedia, the free encyclopedia. For the general protests, see Euromaidan and Timeline of the Euromaidan. Euromaidan protesters Euromaidan militants Sotnia Right Sector.
Law enforcement in Kiev: Timeline of the Euromaidan. This section has multiple issues. Please help improve it or discuss these issues on the talk page.
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List of people killed during Euromaidan. List of communist monuments in Ukraine. Speaker Oleksandr Turchynov named interim president". Archived from the original on 23 February Archived from the original on 16 March Retrieved 12 March Archived from the original on 25 February Archived from the original on 1 March Some 50 people to be charged with organizing killings of Ukrainians".
Retrieved 24 February Archived from the original on 3 August Retrieved 20 July Lenin statues toppled in protest".
Archived from the original on 2 June Retrieved 19 May Retrieved 18 April Zerkalo Nedeli in Russian. Archived from the original on 20 February Retrieved 20 February Retrieved 15 December Retrieved 3 March Lviv Expres in Ukrainian.
Archived from the original on 3 December The bones and the brain are two important tissues in humans where the primary effect of testosterone is by way of aromatization to estradiol.
In the bones, estradiol accelerates ossification of cartilage into bone, leading to closure of the epiphyses and conclusion of growth.
In the central nervous system, testosterone is aromatized to estradiol. Estradiol rather than testosterone serves as the most important feedback signal to the hypothalamus especially affecting LH secretion.
Like other steroid hormones, testosterone is derived from cholesterol see figure. Testosterone is also synthesized in far smaller total quantities in women by the adrenal glands, thecal cells of the ovaries , and, during pregnancy , by the placenta.
Like most hormones, testosterone is supplied to target tissues in the blood where much of it is transported bound to a specific plasma protein , sex hormone-binding globulin SHBG.
In males, testosterone is synthesized primarily in Leydig cells. The amount of testosterone synthesized is regulated by the hypothalamic—pituitary—testicular axis see figure to the right.
These latter two hormones stimulate the testis to synthesize testosterone. The plasma protein binding of testosterone is Testosterone is used as a medication for the treatment of males with too little or no natural testosterone production , certain forms of breast cancer ,  and gender dysphoria in transgender men.
This is known as hormone replacement therapy HRT or testosterone replacement therapy TRT , which maintains serum testosterone levels in the normal range.
Decline of testosterone production with age has led to interest in androgen replacement therapy. Common side effects from testosterone medication include acne , swelling , and breast enlargement in males.
Suffering the ridicule of his colleagues, he abandoned his work on the mechanisms and effects of androgens in human beings. Koch, established easy access to a large source of bovine testicles — the Chicago stockyards — and recruited students willing to endure the tedious work of extracting their isolates.
The chemical synthesis of testosterone from cholesterol was achieved in August that year by Butenandt and Hanisch. Wettstein, published their synthesis of testosterone.
This also made it obvious that additional modifications on the synthesized testosterone could be made, i. The period of the early s to the s has been called "The Golden Age of Steroid Chemistry",  and work during this period progressed quickly.
Research in this golden age proved that this newly synthesized compound—testosterone—or rather family of compounds for many derivatives were developed from to , was a potent multiplier of muscle, strength, and well-being.
Testosterone is observed in most vertebrates. Testosterone and the classical nuclear androgen receptor first appeared in gnathostomes jawed vertebrates.
From Wikipedia, the free encyclopedia. This article is about testosterone as a hormone. For its use as a medication, see Testosterone medication.
For other uses, see Testosterone disambiguation. Hormones and sexual arousal. Williams Textbook of Endocrinology. Therapeutics and Clinical Risk Management.
Testosterone, bone and osteoporosis. Frontiers of Hormone Research. Biosynthesis, transport, metabolism and non-genomic actions".
Action, Deficiency, Substitution 4th ed. The Journal of Clinical Endocrinology and Metabolism. Heroes, rogues, and lovers: American Society of Health-System Pharmacists.
Retrieved 3 September Archives Internationales de Physiologie, de Biochimie et de Biophysique. The European Journal of Neuroscience. Journal of Pediatric Nursing.
The Journal of Biological Chemistry. Journal of Personality and Social Psychology. Archived from the original PDF on April 19, Testosterone and prostate safety.
The Journal of Sexual Medicine. Clinical Interventions in Aging. American Journal of Human Biology. The Journal of Endocrinology. Archives of Sexual Behavior.
Evolution and Human Behavior. Implications for Sexual and Social Behavior". Current Directions in Psychological Science.
Archives of General Psychiatry. International Journal of Impotence Research. The impact of hominin life history evolution on cooperative breeding".
Journal of Human Evolution. Issues, News, and Reviews. Handbook of crime correlates. Direct analysis of candidate genes in impulsive disorders.
Bock G, Goode J, eds. Genetics of Criminal and Antisocial Behaviour. Ciba Foundation Symposium Ferris C, Grisso T, eds.
Understanding Aggressive Behaviour inn Children". Annals of the New York Academy of Sciences. Journal of Clinical Endocrinology and Metabolism.
Journal of Studies on Alcohol. Neuroscience and Biobehavioral Reviews. Archived from the original PDF on January 9, Aggression and Violent Behavior.
Test of Evolutionary Neuroandrogenic Theory". Lay summary — LiveScience 2 March International Journal of Endocrinology and Metabolism.
International Journal of Law and Psychiatry. Journal of Comparative Physiology A. The Journal of Comparative Neurology.
The New England Journal of Medicine. Trends in Endocrinology and Metabolism. Journal of the American Academy of Dermatology.
Int J Mol Sci. Estrogen signaling in the hypothalamus. Dissociating behavioral, autonomic, and neuroendocrine effects of androgen steroids in animal models.
Methods in Molecular Biology. Advances in Experimental Medicine and Biology. Sex and Gender Differences in Pharmacology.
Clinics in Endocrinology and Metabolism. National Academies Press US. Asian Journal of Andrology. European Journal of Clinical Nutrition.
Results from a cohort of severely obese men". Archived from the original PDF on March 27, Food and Chemical Toxicology.
A randomized controlled trial". Principles and Practice of Endocrinology and Metabolism. Curr Opin Endocrinol Diabetes Obes. Ovarian Function and its Disorders: Structure, Function, Regulation and Polymorphism.
Biosynthese, Stoffwechsel, Wirkung in German. Seminars in Reproductive Medicine. Elsevier Health Sciences UK. Estrogens, Estrogen Receptor and Breast Cancer.
Handbook of Drug Interactions: A Clinical and Forensic Guide. Camacho 26 September Styne 25 April Retrieved 5 March Retrieved May 10, Conversion of Dehydro-androsterons into androstendiol and testosterone; a way for the structure assignment of testosterone from cholesterol].
The Journal of Urology. Chemische Berichte in German. Helvetica Chimica Acta in German. An introduction to behavioral endocrinology. Journal Cellular and Molecular Life Sciences.
Perspectives on Neuroprotective and Neurotherapeutic Effects. Molecular Mechanisms of Hormone Actions on Behavior.
Nevada Law Journal, Special Issue: Men, Masculinities, and Law: A Symposium on Multidimensional Masculinities Theory. Chemistry portal Molecular and cellular biology portal Pharmacy and pharmacology portal.
Thyroid hormones T 3 T 4 Calcitonin Thyroid axis. Glucagon Insulin Amylin Somatostatin Pancreatic polypeptide. Allopregnanediol Pregnanediol Pregnanediol glucuronide Pregnanetriol.
Androstanolone stanolone, dihydrotestosterone, DHT Androstanolone esters Bolazine capronate Drostanolone propionate dromostanolone propionate Epitiostanol Mepitiostane Mesterolone Metenolone acetate methenolone acetate Metenolone enanthate methenolone enanthate Stenbolone acetate Nortestosterone derivatives: Bolandiol dipropionate Nandrolone esters e.
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